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DISCOS is an interdisciplinary project of both the biomedical sciences and the humanities to investigate the fundaments of the human person. 10 European centres with outstanding expertise in the area of philosophy, neurosciences, psychiatry and psychology will cooperate in research and training on "Disorders and Coherence of the Embodied Self". Its major goal is the integration of first-person, second-person and third-person approaches to the embodied human subjectivity. DISCOS will investigate how the body "shapes the mind" by its con-tinuous sensorimotor and interpersonal interactions with the environment. It will further investigate how neuropsychiatric disorders of the self are based on dys-functions of these embodied interactions. Embodiment thus constitutes the cru-cial interface of the biological and psycho-social approaches to the human self and its disorders that are integrated by DISCOS. The overall objectives of DISCOS are: 1. On the scientific level: To combine empirical and conceptual research in order to develop a multi-level, dynamic model of the embodied human self and its disorders by determining the role of neurobiological, psychological and so-ciocultural factors for the development of a coherent self identifying dysfunc-tional mechanisms and influences leading to disturbances of self-coherence. 2. On the educational level: To enable young European researchers to acquire high expertise and know how concerning all levels of the self by ? implementing a thorough disciplinary training in one of the core approaches to the self impart-ing an integrative viewpoint and interdisciplinary style of thinking. 3. On the so-cietal level: To bring the framework model of the self to bear on therapeutic in-terventions and ethical perspectives by developing therapeutic guidelines for the integrated use of biological, psychological and social interventions in the treatment of disorders of the self transferring the gained knowledge to relevant social institutions and to the public, in particular, to stakeholders in the public health system regarding therapeutic guidelines. The major breakthrough to be expected from DISCOS will be an integrative framework for research and inter-ventions on the embodied human self that will overcome the fragmentation of approaches and disciplines in the field.